10 Most Gruesome Diseases In Human History

If you hate catching the flu or getting a cold, then you definitely don’t want to catch one of these diseases, cause after you take a look at our list of the 10 most gruesome diseases in human history, you’re gonna be grateful that you just had a slight fever. So with that being said, let’s begin.

10Guinea Worm Syndrome

Guinea Worm Syndrome is Caused by the parasitic worm Dracunculus medinensis and spread in your body by drinking flea contaminated water. There is no available treatment or vaccine. Instead, the worm is removed slowly by winding it around a small stick after it emerges. This may take weeks, and the removal process is very painful.

9Proteus Syndrome

One of the rarest conditions in the world, Proteus Syndrome aka Elephantitis, is a congenital disorder that causes various portions of the body to grow recklessly. Asymmetric bone and skin tumors often cover the skull and limbs—especially the bottom of the feet. There is a theory that Joseph Merrick, the “Elephant Man”, suffered from this same disease.

8Cancrum Oris

Cancrum Oris is an opportunistic infection that likes to hop on board in situations where people are malnourished, have unclean drinking water, poor dental hygiene, and live in close proximity to farm animals. Commonly called Noma, it is gangrene of the face, and infects kids more often than adults. More than 80% of those affected by the disease die, as it eats away at the tissue and muscle around the jaw and face.


One of the most ancient diseases known to mankind, smallpox has also been observed on Egyptian mummies. Just About two weeks after contracting the disease, the body is covered in a painful rash of blood, leaking lesions, not pimples. But After a few days, if you’re lucky enough to survive, the pimple like lesions dry up, leaving behind terrible scarring. George Washington, Abraham Lincoln and Joseph Stalin were all Popular survivor of the small pox disease.


Porphyria is a disorder, which affect enzymes involved in the production of the pigments in red blood cells. In this disease, the patient suffers a major discoloration of the skin when exposed to sunlight. Also, disturbing mutation occurs on various facial parts such as nose eyes and lips. Symptoms of Porphyria include severe abdominal pain, vomiting, neuropathy and mental disturbances.

5Fibrodysplasia Ossificans Progressiva

number five on our list, is one of the most strangest disease ever discovered Fibrodysplasia Ossificans Progressiva, in which, your body’s repair mechanism is completely broken, and starts “healing” the fibrous tissue by turning them into bones. it’s like having a body that never stops growing bones. There’s no known treatment and patient hardly survive past 40 years of age, at which point, their entire body transforms into bone, leaving them completely immobile.


Leprosy, caused by bacteria, can be traced back thousands of years. It starts with ulcers appearing on the skin and growing until victims appear to be rotting away. Although whole limbs don’t fall off, it is common for affected people to lose fingers, toes, and their nose, leaving behind a nightmarish face with ragged holes in the middle. For centuries, victims have been exiled from society, and still till today there are “leper colonies” throughout the world.


The Ebola Virus Disease, is a severe, often fatal illness. Ebola originated from Africa through close contact of blood and other fluids of infected ill or dead animals, such as chimpanzees, gorillas and porcupines. Usually Ebola symptoms start with a fever, sore throat, muscular pain, and headache. Which then leads to blood vomiting, severe diarrhea and massive internal bleeding, that ultimately results in a painful death by liver or kidney failure.

2Tree Man Syndrome

If you thought smallpox was bad, you might wanna see this. Epidermodysplasia verruciformis, simply known as the Tree Man Syndrome, is a very rare skin disorder caused by the papillomavirus and results in horrifying tree-bark-like warts all over the body. There is no specific cure, and the wart removal surgery is proven useless as it grows back immediately.

1Necrotizing Fasciitis

No one cares about Minor cuts and scrapes, but in the presence of flesh-eating bacteria, the smallest of wounds can become life threatening in no time. That’s exactly what happens if you are suffering from Necrotizing Fasciitis. The patient is treated with massive amounts of antibiotics, and all affected flesh must be removed to stop it from spreading. Surgeries often involve the amputation of limbs and other apparent mutilations. Even with medical care, necrotizing fasciitis is lethal in 30-40% of all cases.

And there you have it, our list of the 10 most gruesome diseases in human history. Have we forgotten to mention any other horrible diseases? If so, mention them in the comments section, below. And as always, don’t forget to like, share and subscribe.


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